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Adding neurons to the culture makes the model more representative of the interaction in the NVU and increases the sensitivity of the BBB integrity to oxygen-glucose deprivation [115]

The activation of VIP receptors stimulates the adenylyl cyclase to generate cytosolic cAMP that activate the cystic fibrosis transmembrane conductance regulator (CFTR), resulting in secretion of Cl into the lumen

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It is a cluster of overlapping biological dysfunctions that conventional medicines organ-by-organ approach is poorly equipped to address simultaneously