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Correspondingly, an efficient antioxidant enzyme system exists in the mitochondria, including manganese superoxide dismutase (MnSOD), glutathione peroxidase (GPX), and catalase (CAT), which can effectively scavenge excess ROS and maintain the balance of intracellular ROS levels

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High blood pressure (HBP) is considered both a risk factor and a disease: HBP is a major risk factor for cardiovascular disease, increasing the likelihood of heart attack, stroke, heart failure, and atrial fibrillation

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[13] The appropriate dose is then drawn up into an insulin-type syringe