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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)

That was the safer decision from a warning perspective

However, there is no robust evidence that B12 injections provide benefits to individuals with normal B12 levels

Comprehensive toxicology evaluations reveal that the compound does not affect food intake, body temperature regulation, or basic physiological parameters at effective doses in animal models, indicating that its metabolic effects occur through specific pathway modulation rather than general physiological disruption

Nerve Damage Due to Other Causes Injections of vitamin B12 aid in the repair of peripheral neuropathy brought on by conditions other than a B12 shortage