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doi: 10.3389/fnins.2020.601193 Received 31 August 2020 Accepted 04 November 2020 Published 08 December 2020 Volume 14 - 2020 Edited by John Zhang, Loma Linda University, United States Reviewed by Carmen Rubio, Instituto Nacional de Neurologa y Neurociruga Manuel Velasco Surez, Mexico

Endothelial LRP1a potential target for the treatment of Alzheimers disease : theme: drug discovery, development and delivery in Alzheimers disease guest editor: davide brambilla

p53 is associated with the two key kinases of ataxia telangiectasia and rad3-related protein-checkpoint kinase 1 pathway [45] that induce the transcription of cell cycle suppressor p21 gene and delay damaged G1 cells from entering S phase, preventing new start events at the beginning of the duplication process and slowing down the branching processes of reproduction of UV-irradiated cells in the S phase

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AOD-9604 may also contribute indirectly by improving body composition, which can influence overall energy balance