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The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

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Furthermore, VEGF may also increase the permeability of blood vessels, which might enable the extravasation of plasma proteins and contribute to the formation of a primitive vascular scaffold, thereby potentially promoting the process of angiogenesis

However, when endogenous stimuli are considered, excessive ROS may also stem from melanogenesis