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When the lactate concentration in the brain exceeds 10 mM, lactate induces aberrant histone lactylation (e.g., overactivation of H3K18la) (Ran et al., 2026)

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In Alzheimers disease, this cleanup crew can become exhausted, so some researchers think they can treat the disease by coaxing the cells back into action

Vagal tone is reduced during paced breathing in patients with the chronic fatigue syndrome

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