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[DOI] [PubMed] [Google Scholar] 7.Brown C.J., Mackinnon S.E., Evans P.J., Bain J.R., Makino A.P., Hunter D.A., Hare G.M

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AEs included increased serum creatinine (some cases managed by adjusting dose downward), hypertension (managed with anti-hypertensive meds), alopecia, cutaneous lymphoma, mouth ulcers, and acute gout (managed with allopurinol)

Methylated CpG islands are typically associated with heterochromatin, partly due to the recruitment of methyl-CpG binding proteins, which in turn recruit histone deacetylases and other chromatin-remodeling complexes to promote transcriptional repression (Hashimoto et al., 2010)