Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)
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Discovery of 1,6-naphthyridin-2(1 H )-one derivatives as novel, potent, and selective FGFR4 inhibitors for the treatment of hepatocellular carcinoma
The study's findings showed that in immunocompetent mice bearing experimental melanoma, SPIONs containing 5-FU demonstrated increased skin penetration as well as enhanced tumor development retardation when compared to Doxorubicin