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They reported that p53 suppresses accumulation of cytoplasmic chromatin fragments (CCF), including DNA damage signaling marker H2A.X, and its downstream inflammatory phenotype (e.g., SASP) of monocytes and macrophages in liver

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(5) IIRI + MET + Abx group: administered oral antibiotics (ampicillin 1 g/L, neomycin 1 g/L, metronidazole 1 g/L, and gentamicin 160 mg/L) combined with metformin in drinking water for one week prior to IIRI

However, if gut repair is the focus, this is recommended as an oral supplement

10.1016/j.jchemneu.2018.03.002 40 KhodayarM