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The protective mechanism of donepezil was achieved by inhibiting the production of NO, proinflammatory cytokines, the TLR-4/NF-B/NLRP3 inflammasome pathway, and apoptosis (Zidan et al

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Using bioinformatics and metabolomics approach together with in vitro and in vivo gametocytogenesis assays we show that the absence of key enzymes in the transsulfuration pathway contribute to the accumulation of redox metabolites such as homocysteine, which trigger the pathway for sexual stage conversion