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It has been observed that glutamate production through the appropriate function of GDH pathway has a role in the mitochondrial retrograde signaling that affects changes in nuclear gene expression related to nutrient sensing and TOR signaling [26, 98], aging [99, 100] metabolism [20] and as recently shown, in different types of cancer [101,102,103,104,105,106,107,108]

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We also expect to revise the budget neutrality offset amount upon calculating the actual costs of the demonstration for FY 2018, after ( receiving all of the finalized cost reports for that fiscal year

However, pharmaceutical development expensive ($100M+ for full approval process) requiring corporate investment

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