Related symptoms may include gastrointestinal upset, brittle nails, hair loss, and in more severe cases, neurological effects [92]
Neurotrophins such as nerve growth factor, brain-derived neurotrophic factor and hepatocyte growth factor (HGF) are capable of stimulating dendritic arborization, synaptogenesis, stem cell differentiation, neurogenesis, and decreases in neuroinflammation, oxidative stress-induced damage and neurotoxicity due to a wide range of cellular insults
In: Feingold KR, Anawalt B, Blackman MR, et al, eds
However for most people with ALS, there is a gradual onset of symptoms
The recommended daily intake of 1,073 milligrams of RRR--tocopherol or its esters is currently recommended, yet the safety implications of exceeding this dosage warrant further investigation (72)