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These factors include preexisting bowel disease, a low-fiber diet, straining with defecation, and vascular engorgement due to increased pressure caused by the enlarging abdomen

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Caffeic acid also increases the activity of antioxidant enzymes, reducing the risk of free radicals and oxidative damage

Taking the supplement along with these medicines can cause a condition called serotonin syndrome, which can lead to agitation, confusion, high fever, rapid heart rate, muscle stiffness and, in severe cases, seizures or even death

Laureys, D., Cnockaert, M., De Vuyst, L., & Vandamme, P