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Because the drug lingers in the body for so long, skipping a dose occasionally does not cause severe side effects, says Tatiana Figueredo-Dietes, MD, an obesity medicine physician at NYC Health + Hospitals, Bellevue

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In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population

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