When AOD-9604 binds to these receptors, it triggers a signaling cascade that increases cyclic adenosine monophosphate (cAMP), activates protein kinase A, and ramps up hormone-sensitive lipase activity
Journal of Drug Delivery and Therapeutics 11(1): 130137
50 TortoraG.OrsiniB.PecileP.MenciassiA.FusiF.RomanoG.et al (2016)
Promotes Neuroprotection and Longevity NAD+ also activates sirtuins, proteins that regulate cellular health, repair DNA, and protect neurons
In mice, 3-AR receptors mediate cold-induced thermogenesis (223) and pharmacological activation of 3-ARs acutely stimulate lipolysis leading to two-fold increase in energy expenditure, a dramatic ten-fold increase in insulin levels, and 4050% reduction in food intake (98)