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Microglial activation occurred at 12 months, astrocyte activation at 18 months, and neuronal loss and synaptic loss in the CA3 region of the hippocampus were evident by 18 and 8 months, respectively

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Inhibition of SHMT2 catalytic activity during embryonic development leads to insufficient dTTP supply and replication stress during the first mitosis, resulting in failure of pronuclear fusion and developmental arrest [37]

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