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Compounds such as thalidomide and its analogs lenalidomide and pomalidomide promote interactions between E3 ligases (e.g., cereblon) and specific target proteins, triggering their ubiquitination and proteasomal degradation

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Kumar Ponnusamy* et al., Impact of Poly(ADP-ribose)Polymerase (PARP-1) Modulators on the Biomarkers of Alzheimers Disease in Aged Mice