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Helps strengthen the moisture barrier, provides antioxidant protection, and slows aging

ROS damage cellular lipids, proteins, and DNA, also triggering further immune responses that target melanocytes

Cell surface biotinylation further showed ZIP8 and ZIP14 on both membranes of human brain microvascular endothelial cells (hBMVECs), with ZIP8 more abundant apically and ZIP14 basolaterally, though not statistically significant (Steimle et al., 2019)

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