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Appl Biochem Biotechnol 168:198205

Another study also revealed that 48% of patients with stage 3 or 4 DKD had cognitive dysfunction and neurocognitive disorders (111)

Some intriguing examples, also in mouse models of AD, come from the use of transcranial focused ultrasound that, combined with circulating NPs, could permit the transient opening of discrete sites on the BBB, showing large potential for AD treatment, such as a significant reduction in plaque burden (Jordo et al., 2013