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Granny smith apple procyanidin extract upregulates tight junction protein expression and modulates oxidative stress and inflammation in lipopolysaccharideinduced Caco2 cells

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13A) showed a positive correlation between Moheibacter , Cnuella , Gaetbulibacter , Lacibacter , alpha-linolenic acid, MPO gene expression, and IMF content, while N,N,N-trimethyllysine, L-carnitine, and betaine were negatively correlated with MPO gene expression

Notably, the requirement for mitochondrial metabolism varies by the ferroptotic trigger: while essential for cystine-deprivation-induced ferroptosis, its significance diminishes when ferroptosis is initiated by direct GPX4 inhibition, highlighting distinct metabolic dependencies [67,74]

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