Eleven percent of children may experience long-term sequelae, such as autoimmune diseases (most commonly hypothyroidism, 3.8%).27,42 Histopathological changes The histopathology of DRESS varies depending on the stage of the disease and clinical manifestations and, since there are no pathognomonic findings, correlation with clinical and laboratory criteria is necessary for a definitive diagnosis
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In another study of ADI-resistance using melanoma cell lines, all ADI-resistant cells displayed enhanced ASS1, GLS1, and GDH protein expressions mediated by up-regulated c-myc, comparing to parental cell lines [145]
Nrf2, nuclear factor erythroid 2-related factor 2
Multiple-Dose Flexibility: Contains benzyl alcohol as a preservative, allowing for repeated withdrawals from the same vial