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The three proline residues at positions 35 (the PPP motif) rigidify the chain and hinder access by proteolytic enzymes a molecular explanation of the peptide stability in the gastrointestinal environment described in the literature

In vivo murine models revealed that radiolabeled (indium, 111 In) CooP peptide can be utilized for homing to glioblastoma-bearing mice in SPECT-CT for diagnostic imaging [93]

At picomolar to nanomolar concentrations, GHK-Cu stimulates collagen synthesis in skin fibroblasts while increasing accumulation of total proteins, glycosaminoglycans, and DNA in dermal tissues

doi: 10.1021/acs.jafc.2c01196 41 NieuwenhuizenLSchutgensREvan AsbeckBSWentingMJvan VeghelKRoosendaalGet al