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Figure 6 Crystal structures of IRAP were recently solved (Hermans et al., 2015

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Ferroptosis is negatively regulated by the enzymatic activity of GPX4, and increasing attention to possible ways of inhibiting this cell death modality are needed ( In order to test if our new activator could have a beneficial effect in the context of inhibiting cell death, we evaluated compound 102 for its ability to prevent erastin-induced ferroptosis

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