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2,3 The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb.) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb.) for the placebo group which was statistically significant

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Peptides were eluted at a flow rate of 600 ml/min with a linear gradient of 535% solvent B (acetonitrile) over 10 min

The published research base, predominantly preclinical with growing clinical extension, identifies several mechanisms of action