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Glutathione is produced naturally in the body, but its levels can deplete due to ageing, stress, poor diet, and exposure to toxins

GSSG is a product of the oxidation of GSH, which has no biological activity and needs to be reduced to GSH by consuming energy under the action of enzymes in order to resume its function

"Glutathione in foods listed in the National Cancer Institute's Health Habits and History Food Frequency Questionnaire." Nutr Cancer

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As a result of this reaction, cellular glutathione concentration tends to be depleted in the presence of acetaminophen