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These potential applications are supported by small RCTs and mechanistic studies indicating ECM remodeling, antioxidant effects, and anti-inflammation [1, 2, 3, 5, 8]

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The GHK sequence also appears within the alpha-2(I) chain of type I collagen, leading to the hypothesis that collagen degradation at wound sites releases GHK fragments that then bind copper and signal for new collagen production, creating a self-repair feedback loop

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10.1016/j.biopha.2014.06.001 109 van den BoschA