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Topical applications are often once or twice daily, while injectable protocols might be daily or every other day

Vitamin B12 status in women of reproductive age, NHANES 20132014. The FASEB Journal 31 (2017): lb439-lb439

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(6) Homocysteine also rises with low B12, though it is less specific because folate status and kidney function move it as well

[1] However, whilst acute toxicity is rare, elevated serum B12 levels can occasionally occur and may warrant investigation, particularly when they arise unexpectedly or in the context of certain medical conditions