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Mary`s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea 18 Division of Respiratory Medicine, Soon Chun Hyang University Hospital Cheonan, Cheonan, South Korea 19 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea Funding This study was funded by the Boryung Pharmaceuticals