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Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients

Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter

Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin

This can result in an increased susceptibility to metabolic stress, a factor that greatly accelerates the aging process

The GRAS determination was likely based on the compound's limited systemic absorption (when ingested), short plasma half-life, and lack of acute toxicity signals in the Phase 2b obesity trial