By activating the Nrf2/HO-1/GPX4 pathway, it inhibits ferroptosis in podocytes, thereby exerting its renal protective effect (144)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Travis WD, Dacic S, Wistuba I, Sholl L, Adusumilli P, Bubendorf L, Bunn P, Cascone T, Chaft J, Chen G, Chou TY, Cooper W, Erasmus JJ, Ferreira CG, Goo JM, Heymach J, Hirsch FR, Horinouchi H, Kerr K, Kris M, Jain D, Kim YT, Lopez-Rios F, Lu S, Mitsudomi T, Moreira A, Motoi N, Nicholson AG, Oliveira R, Papotti M, Pastorino U, Paz-Ares L, Pelosi G, Poleri C, Provencio M, Roden AC, Scagliotti G, Swisher SG , Thunnissen E, Tsao MS, Vansteenkiste J, Weder W, Yatabe Y
Aono S, Yamada Y, Keino H, Sasaoka Y, Nakagawa T, Onishi S et al
Monitoring: During the infusion, the healthcare provider monitors the patient for any adverse reactions or discomfort