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While resmetirom remains the only FDA-approved therapy to date, experimental agents such as elamipretide (SS-31) and uncoupling protein 2 (UCP2) modulators are under investigation to restore mitochondrial integrity and reduce ROS production [103106]

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l-glutamic acid -benzyl ester N -carboxyanhydride (BLG NCA) was prepared following the reported protocol [44, 46]