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Owing to its low cost and simplicity, in vitro cellular experiments are routinely used to assess metel-based NP toxicity, allowing deeper investigation into molecular mechanisms

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ACTL6A knockdown (KD) via short hairpin RNA (shRNA) transfection exerted a marked negative effect on GC cell proliferation, while overexpression of ACTL6A exerted a positive effect on GC cell proliferation (Fig

The original Phase III trials did not require bedtime dosing