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This work received funding from Science Foundation Ireland and National Childrens Research Centre/Childrens Health Ireland through the Precision Oncology Ireland grant 18/SPP/3522, the Science Foundation Ireland Frontiers for the Future Program grant 22/FFP-A/10729, and with the financial support of Childrens Health Foundation and under the management of Science Foundation Ireland under the Frontiers for the Future Program Grant Number 21/FFP-P/10130