Findings that would support a primary metabolic defect in copper metabolism include a previously recognized breed predisposition, copper accumulation that precedes cholestasis or inflammation, centrilobular (zone 3) distribution of copper, histochemical score for copper of 3+ or greater, or quantitative copper measurements that exceed 2000 g/g dry weight.54, 57, 66 Special stains of the liver should be requested to evaluate for infectious agents such as leptospirosis
Common 1-3 Contraindications 1-3 Hypersensitivity to GHK, copper peptides or excipients Active local infection, open wounds, or compromised skin barrier at site of application Precautions 1-3 Avoid contact with mucous membranes and eyes This information is for educational purposes only
Patricia Marris | Bristol | March 2025
Compared to patients with TLE, those with the TLE-D phenotype exhibit more extensive structural and functional brain abnormalities, including reduced gray matter volume in cortical and subcortical regions, cerebellar damage, and white matter microstructural changes
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