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JAM-C can maintain the EC in a polarized manner, creating a unidirectional gate for neutrophil movement from the vascular lumen to the proximal tissue compartment, whereas the effects of NE and certain acute inflammatory conditions, such as ischemia-reperfusion injury, may impair this gate by downregulating the expression of JAM-C

Opioid excess theory One of the theories proposed in the pathogenesis of ASD is the opioid excess theory (Tarnowska et al