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A small hole is drilled into the apical turn of the cochlea, and 1-2 mls of cold PFA are slowly perfused through the apical hole

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The same salutary effects mediating MACE reduction by dulaglutide, such as amelioration of glucose control, blood pressure, dyslipidemia, BW and probably endothelial function and oxidative stress, are likely involved in ED prevention and improvement 100

Importantly, these changes were observed without significant reductions in food consumption, pointing to enhanced energy metabolism rather than appetite suppression as the primary mechanism