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GHK-Cu exerts its effects primarily through gene expression modulation, influencing approximately 31% of the human genome by upregulating genes involved in antioxidant responses, DNA repair, protein metabolism, and cellular growth while downregulating inflammatory mediators, fibrinogen synthesis, and pathological processes including cancer metastasis

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The black box warning on GLP-1 receptor agonists stems from animal studies showing C-cell hyperplasia and medullary thyroid cancer in rodents