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Meta-analyses and reviews of clinical studies based on the measurement of BDNF in whole blood, serum, or plasma have reported significantly lower BDNF levels in patients with major depression 11,12 , schizophrenia 13 , bipolar disorders 14 , or autism spectrum disorders 15,16

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By improving insulin sensitivity and reducing overall insulin demand, GLP-1 RAs address one of the primary drivers of the condition not just a symptom