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beyond its lipid effects, berberine improves endothelial function and induces vasodilation via increased NO and via activating AMPK ( In vivo studies indicate that berberine can lower blood pressure in spontaneously hypertensive rats, with effects on the renin-angiotensin system and improved arterial compliance

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Copper(II) The +2 oxidation state of copper, the form bound by GHK and by most cellular copper-binding proteins