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They simply lose their ability to bind to GLP-1 receptors effectively

Therefore, a bypassing key, i.e., an activated azygos vein as a rescuing pathway, avoiding both the lung and liver and also noted in BuddChiari syndrome (i.e., suprahepatic occlusion of the inferior caval vein) (Gojkovic et al., 2020), combines the inferior caval vein and superior caval vein via direct blood delivery