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Hepato(geno)toxicity assessment of nanoparticles in a HepG2 liver spheroid model

Front Pharmacol 11:600255 Zhao M, Ma J, Li M, Zhang Y, Jiang B, Zhao X et al (2021) Cytochrome P450 enzymes and drug metabolism in humans

doi: 10.1111/j.1463-1326.2010.01266.x

If triglycerides rise above 500 mg/dL on repeat testing, most guidelines recommend reducing the isotretinoin dose or temporarily stopping the drug until levels normalize