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While lifestyle management remains the first-line treatment for obesity, it is often limited by counterregulatory physiological changes that make sustained weight loss challenging

The bone effects of amylin analogues also deserve investigation, as these drugs not only bind the amylin receptors AMY1R, AMY2R, and AMY3R, but also the calcitonin receptor, raising the possibility of direct effects on bone metabolism [10]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Rotigotine transdermal patch for motor and non-motor Parkinson's disease: a review of 12 years' clinical experience

Am J Physiol Renal Physiol 293(4):F1363F1372