For instance, upregulating GPX4 in ferroptosis-sensitive chondrocytes, restoring antioxidant defenses in inflammatory synovial macrophages, or rebalancing iron export in subchondral osteoblasts may prevent tissue-specific degeneration
Lipo for lipids, and shield because they form a protective barrier around the nutrients, helping to deliver them through the digestive system
Therefore, targeting the Gln metabolic network represents a unique opportunity to overcome therapeutic resistance and sensitize tumor cells to anticancer treatments, potentially offering greater benefit than AR-targeted monotherapy (39, 168)
Mitohormesis In 1932, a biphasic response to harmful substances was described, called hormesis [156]
Integrative Medicine, 13(1), 812