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et al., The New England Journal of Medicine , 2023, 10.1056/NEJMoa2301972 Study Objective To evaluate the efficacy, safety, and dose-response effect of Retatrutide a triple GIP, GLP-1, and glucagon receptor agonist in adults with overweight and obesity

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Typically, high microbial diversity correlates with good health and fitness, as cardiorespiratory fitness accounts for roughly 20% of gut diversity variation [36]

Overexpression of the leptin gene in adipocytes and increased circulating levels of leptin may also contribute to enhanced basal lipolysis in obesity (74)