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Using in vivo and ex vivo ischemia-reperfusion models, ozone treatment was shown to reduce myocardial injury by regulating ferroptosis-related proteins and transcription factors, particularly enhancing Nrf2 nuclear translocation, thereby exerting cardioprotective effects (35)

10.1097/jcp.0000000000001324 44 HewlingsS

Time courses typically run 14 to 28 days for tendon endpoints and 60 to 90 days for ligament endpoints

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