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Aging microbiota-gut-brain axis in stroke risk and outcome

(105) found that FP cell-free supernatant exerts non-butyrate-dependent anti-inflammatory effects by reducing colonic TNF-/IL-12 and increasing serum IL-10

p53 tumour-suppressor caution Because FOXO4-DRI intervenes in the p53 pathway, which is critical for tumour suppression, there is theoretical concern that interfering with p53 dynamics might carry oncogenic risk

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The induction of the antimicrobial peptide gene expression is mostly initiated by binding of transcription factors like NF- B, AP-1, and STAT3 [26] due to activation of Toll-like receptors by microbial antigens or initiated by cytokines [27]