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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

The methods comprise the step of administering to the patient an amount of one or more hepatocyte growth factor mimics sufficient to reverse, ameliorate or slow progression of the at least one symptom

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