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Co-transfection of cells with the EAAT3 promoter-driven luciferase reporters, specifically WT-luc, followed by treatment with TNF or co-transfection with P65, led to the activation of luciferase activity with the wild-type EAAT3 promoter (WT-TNF or WT-P65)

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xCT is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11) that enhances cystine uptake and GSH biosynthesis, thereby inhibiting oxidative stress and iron death (Liu L

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