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As shown in Figure 2B, after the administration of peroxynitrite, the SGN morphology was disrupted and pyknotic, cells arrangement was disordered, nerve fibers were disordered, broken, or lost
Out of four peptide drugs in the market which have reached global sales over $1 billion, three peptides are used in treating cancer directly or in the treatment of episodes associated with certain tumors (leuprolide, goserelin, and octreotide)
showed that changes in SDC-1 mechanical tension generate a tension gradient in SDC-1 under fluid shear force, with SDC-1 interacting differently with the cytoskeleton depending on substrate stiffness, affecting integrin-mediated signaling and focal adhesion formation [49]
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