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In fact, fluid retention as a result of venous insufficiency is common, with the National Library of Medicine reporting that anywhere between 1-40% of females and 1-17% of males report suffering from venous insufficiency

10.1089/ars.2011.3904 Summary Keywords nitric oxide, eNOS, endothelium, preclinical evidence, clinical trials Citation Gonzalez M, Clayton S, Wauson E, Christian D and Tran Q-K (2025) Promotion of nitric oxide production: mechanisms, strategies, and possibilities

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